Liposomes that Encapsulate Drugs in the Hydrophilic Region
Hydrophilic drugs are retained within the aqueous core area of liposomes. For example, Liposomal Doxorubicin Injection is liposome-encapsulated doxorubicin within the hydrophilic pocket and coated with PEG (polyethylene glycol) to evade detection and destruction by the immune system. The PEG coating improves the stability and lengthens the half-life in the circulation. Our first liposome product, Lipo-Dox ®, is in this category.
For global commercial supply, TTY has an automated-skid for liposomal injection in Chungli Factory.
Liposomes that Encapsulate Drugs in the Hydrophobic Region
Hydrophobic drugs are situated within the hydrophobic region of the bilayer. For example, Liposomal Amphotericin B injection (Lipo-AB®) is composed of liposomes containing amphotericin B (AmB) intercalated within the membrane. AmB is an effective but toxic antifungal drug, known to increase the permeability of the cell membrane, presumably by assembling into transmembrane pores in a sterol-dependent manner. The aggregation of AmB molecules in a phospholipid bilayer is crucial for the drug's activity. Liposomal preparations of AmB have the advantage of lower toxicity compared with conventional preparations.
For global commercial supply, TTY is establishing dedicated facilities for lyophilized liposomal injection in Lioudu factory.
Liposomes that Contain Targeting Ligands
Although clinically useful antitumor activity has been demonstrated with passively targeted liposomes, an additional level of sophistication and specificity for tumor cells can be achieved through ligand-mediated targeting, also known as active targeting. This involves the coupling of targeting ligands such as monoclonal antibodies, antibody fragments, proteins, and peptides to the surface of a liposome to selectively target tumor cells that overexpress a particular cell surface receptor. Active targeting of liposomes can significantly increase the amount of drug delivered to the target cell compared to delivery of the free drug or passively targeted liposomes.
Liposomes that encapsulate Macromolecules
Cationic liposome-DNA complexes are regarded as promising materials for safe and efficient delivery of genes for therapeutic applications. Cationic liposomes react spontaneously with the negatively charged DNA molecules (self-assembling system), forming complexes with DNA molecules participating in the reaction.